Peptide nasal sprays offer an easy and convenient way to deliver peptide therapies. This delivery method has proven to be highly effective when treating neurodegenerative diseases such as Alzheimer’s, and mental health conditions including schizophrenia. Peptide nasal sprays can be administered by spraying them directly into the nose, bypassing the digestive system and reaching the brain faster.
The peptide developed by Moscona and Porotto recognizes SARS-CoV-2’s spike protein, wedges itself into the unfolded region, and prevents the protein from adopting the compact shape needed for fusion with other proteins in the cell membrane. This essentially shatters the spike’s ability to infect cells, and in experiments using ferrets, the peptide prevented infection even after direct contact between two uninfected cagemates.
Scientists have also discovered that inhibiting neurabin with their peptide enabled increased action by A1C, which reduces excess electrical activity in the brain that causes seizures and protects neurons in Alzheimer’s models. Adding the A1R-CT peptide to their nasal spray formulation allows them to tamp down this uncontrolled electrical activity, which is common after traumatic brain injury or stroke and affects more than half of people with Alzheimer’s.
The team is now working to develop a commercial version of their peptide nasal spray. They hope to rapidly advance the preventative treatment into human trials, with the ultimate goal of deploying it to help contain transmission during this pandemic.peptides for sale